CS-ET reconstructions from a combination of I-DS (rows) and T-DS (columns) settings. (a-d) correspond to 100% I-DS setting, (e-h) to 60%, (i-l) to 30% and (m-p) to 10%. Each row shows reconstructions obtained with 2°, 4°, 6° and 8° T-DS settings. I-DS tilt series were restored by TV inpainting prior to CS-ET reconstruction. Red insets in (d) and (f) show the reconstructed pores obtained with a relative dose of 0.25 and 0.3, respectively, compared to the fully sampled reconstruction (yellow inset in (a)). Green insets in (k) and (m) both show the reconstructed pores obtained with a factor of 0.1 dose reduction but using different I-DS and T-DS settings. Scale bar: 200 nm.