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Table 1 Dose reduction by I-DS and T-DS approaches

From: Reduced-dose and high-speed acquisition strategies for multi-dimensional electron microscopy

I-DS (% of pixels sampled) T-DS (angular increment) Relative dose Resolution (FSC = 0.3) (nm)
100 2° (70 projections) 1.0 6.31
100 8° (18 projections) 0.25 11.7
60 4° (35 projections) 0.3 7.69
30 4° (35 projections) 0.15 8.21
30 6° (24 projections) 0.1 8.8
10 2° (70 projections) 0.1 8.2
  1. I-DS, image-downsampling; T-DS, tilt-downsampling; FSC, Fourier Shell Correlation. Summary of selected I-DS and T-DS settings with the corresponding relative dose and resolution of the CS-ET reconstructions (Fourier Shell Correlation (FSC) = 0.3).